Tau441 (2N4R) mutant Protein Monomer
The Tau441 (2N4R) mutant Protein Monomer is For Research Use Only
Specificity: ~45.8 kDa
Species: Human
Expression System: E. coli
Buffer: 10 mM HEPES, 100 mM NaCl pH 7.4
Storage Temperature: -80ºC
Alternative Names: Active Human Recombinant Tau441 (2N4R), P301S mutant Protein Monomer, Active tau monomer, active tau protein monomer, active tau protein, microtubule-associated protein tau, MAPT, MAP, microtubule-associated protein, tau-441, Paired Helical Filament-Tau, Phf-Tau, Neurobrillary Tangle Protein, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Isoform 2, tubulin-associated unit
Product manufactured in Canada by StressMarq.
Assay Background
Alzheimer’s Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65. It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907. Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils. There are six isoforms of tau in the adult human brain: three with four repeat units (4R) and three with three repeat units (3R). 2N4R, or Tau-441 is the full length tau protein. P301S is a mutation encoded by exon 10 that impairs the ability of tau to assemble microtubules.
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