Tau K18 P301L mutant Preformed Fibrils


The Active Human Recombinant Tau K18 P301L mutant Preformed Fibrils are intended for research use only and are not for use in diagnostic procedures. Contact us for bulk pricing.

SKU: SPR-330B Categories: ,

Tau K18 P301L mutant Preformed Fibrils

The Tau K18 P301L mutant Preformed Fibrils is For Research Use Only

Specificity: ~15.1 kDa
Species: Human
Expression System: E. coli
Buffer: 10 mM HEPES, 100 mM NaCl pH 7.4
Storage Temperature: -80ºC
Alternative Names: Active Human Recombinant Tau (K18), P301L mutant Protein Preformed Fibrils, Active tau PFFs, active tau protein preformed brils, active tau aggregates, microtubule-associated protein tau, MAPT, MAP, microtubule-associated protein, Paired Helical Filament-Tau, Phf-Tau, Neurobrillary Tangle Protein, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Isoform 4, tubulin-associated unit

Product manufactured in Canada by StressMarq.

Assay Background

Alzheimer’s Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65. It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907. Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils. There are six isoforms of tau in the adult human brain: three with four repeat units (4R) and three with three repeat units (3R). K18 is a truncated form of human tau containing only the 4 microtubule binding repeats. P301L (PL) is a mutation where proline is replaced by leucine at codon 301 of tau, and has been linked to frontotemporal dementia.

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Additional Information

Comparative Protein Graph

Tau K18 P301L mutant Preformed Fibrils

Package Inserts

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