Tag: noggin

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Evaluation of NOGGIN and ASPORIN as new biomarkers for diagnosis of NAFLD

by Eagle Biosciences

Eagle Biosciences partner Fianostics completed a study evaluating their Noggin and Asporin FluoBolt assays as biomarkers for non-alcoholic fatty liver disease (NAFLD). The study shows that NOGGIN and ASPORIN may be valuable biomarkers for the diagnosis of NAFLD patients and they may also mediate the favorable effect of vitamin E treatment, although mechanistic studies are needed. Further studies with higher patient numbers are also required to confirm these promising results. The study helps support that these highly sensitivity assays allow researchers to measure a decrease of both markers in samples from NAFLD patients. This measurement is not possible with less sensitive methods. This indicates that noggin and asporin may be valuable biomarkers for NAFLD diagnosis.

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FluoBolt Kits:
Noggin
Asporin

Contact us for more information about these kits or our other FluoBolt offering.

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Biomarker Spotlight: Noggin

by Eagle Biosciences

Noggin is a secreted homodimeric glycoprotein that is involved in the development of many body tissues, including nerve tissue, muscles, and bones. Noggin is crucial during embryogenesis and is involved in the regulation of several developmental processes, including neural tube formation, cardiomycyte growth, skeletal development, and joint formation. Noggin is highly conserved in vertebrates, and is found in certain areas of the central nervous system, lungs, skeletal muscles, and skin of adults.

Why is it important?

Research has shown that noggin plays a role in learning, cognition, bone development, and neural tube function, as well as nervous system, somite and skeletal development. A lack of noggin during embryo development can lead to stunted bone growth, missing skeletal elements, or failure to develop articulating joints. Mutations of the noggin gene can cause joint fusions, multiple synostosis, proximal symphalangism and other deformities or syndromes.

In adult patients, increased levels of noggin in plasma have been linked to obesity.

NOGGIN has also been linked to:
Bone Tumors
Ankylosing Spondylitis
Non Alcoholic Fatty Liver Disease (NAFLD)
Pulmonary Arterial Hypertension (PAH)

Eagle Biosciences offers a highly sensitive Metal Enhanced Direct Sandwich Fluorescence Immunoassay to test for Noggin.
FluoBolt-Noggin Fluorescence Immunoassay

Contact us for more information about our Noggin Assay.

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Eagle Welcomes Fianostics!

by Eagle Biosciences

 

Eagle Biosciences, Inc. is excited to collaborate with Austrian biotech Fianostics, to offer a new fluorescence-based detection platform for immunoassays, called FluoBolt™, which enables highly sensitive assays with high reproducibility and reliability. This dramatically improves the informative value of research with biomarkers.

So far, Fianostics FluoBolt™ Metal Enhanced Fluorescence Immunoassays have been developed to detect

What Makes These Assays Different?

Fianostics FluoBolt™ Metal Enhanced Fluorescence Immunoassays have been established to eliminate the complicated processes that come with your standard sandwich ELISA. By using their FluoBolt™ Metal Enhanced Fluorescence Immunoassays, you can expect
  • High Sensitivity!
  • Single Step Assay Procedure!
  • No Enzyme Substrate!
  • Stable Signal over Time!
  • 100% Compatibility with 96-well ELISA Format!

About Fianostics

Fianostics combines scientific and technical expertise in diagnostics with the development of a high-tech detection platform that benefits in reproducibility from the excellent expertise of Sony DADC BioSciences in the production of polymer consumables for the diagnostic industry. Their know-how is not limited to the development of the new detection platform, but we also provide the diagnostic application with the appropriate immunoassays for specific clinical areas. (for research use only in the US)

About Metal Enhanced Fluorescence

Metal Enhanced Fluorescence (MEF) offers the possibility to dramatically increase the analytical sensitivity of systems based on fluorescence detection. MEF is based on the fact that excitation light interacts with the electrons of metal nano–structures thus generating very high electromagnetic fields (Localised Surface Plasmons, LSPs ) Therefore, such structures are also called
”plasmonic structures” and the combination of (e.g, polymeric) support and structure is known as “plasmonic substrate”. These LSPs lead to an increase in emission output of fluorescent molecules (e.g. fluorescently labelled antibodies) when bound to surfaces with suitable nano-metal structures that can enhance the signal more than 100 times.