Tag: Eagle Biosciences

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EagleBio’s 25 OH Vitamin D ELISA Cited in University of Florida Study

by Eagle Biosciences


A recent
study was conducted by the University of Florida, Gainesville using
Eagle Bioscience’s 25-OH Vitamin D
ELISA from our Vitamin Assay Kit Line.
The Vitamin Assay
Kit line offered Eagle Biosciences provides unique and sensitive
assays for measuring a variety of vitamin analytes in numerous fields of
research. Check the product page for full details on our 25-OH Vitamin D
ELISA or view the links below for information about the study
referencing this kit.

Publication: 

Nelson, C. et al.  Vitamin D status of dairy cattle: Outcomes of current practices in the dairy industry. Journal of Dairy Science. December 2016, Volume 99 :12: 10150–10160. DOI: https://dx.doi.org/10.3168/jds.2016-117

“The need for vitamin D supplementation of dairy cattle has been known for the better part of the last century and is well appreciated by dairy producers and nutritionists. Whether current recommendations and practices for supplemental vitamin D are meeting the needs of dairy cattle, however, is not well known. The vitamin D status of animals is reliably indicated by the concentration of the 25-hydroxyvitamin D [25(OH)D] metabolite in serum or plasma, with a concentration of 30 ng/mL proposed as a lower threshold for sufficiency. The objective of this study was to determine the typical serum 25(OH)D concentrations of dairy cattle across various dairy operations….” Read More 

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Product Highlights: ILite® Anti-CD20 ADCC Activity Set

by Eagle Biosciences

ILite® Anti-CD20 ADCC Activity Set is for Research Use Only in the US.  Not to be used for Diagnostic Procedures.

Eagle Biosciences is proud to announce the launch of the iLite ADCC Activity Assay product line and the iLite anti-CD20 ADCC Activity Set.

Rituximab, a chimeric monoclonal antibody against CD20, was one of the first therapeutic antibodies within the oncology field to receive approval by the FDA in 1997. Ever since biosimilar and innovative biologicals with similar mechanism of action have been developed and marketed.

Antibody-dependent cell-medicated cytotoxicity (ADCC) can now, using our new iLite®ADCC Activity Assays, be measured in a straight forward, sensitive and reproducible manner.

ILite® Anti-CD20 ADCC Activity Set is a great addition to EagleBio’s Drug Monitoring kit Line which offers a unique grouping of products that provide incredible value to pre-clinical and clinical pharmacology studies, cancer research, and more specifically anti-tumor therapeutic investigation and more.

Key Advantages

The iLite® anti-CD20 ADCC Activity Set

  • Comprehensive kit– Contains 3 different genetically modified cell lines (components also available separately):
    1. Reporter Effector cell,
    2. Positive Target cell
    3. Negative Target cell
  • Fast- results in 5 hours- this set of cells enables measurements of an anti-CD20 drug’s ability to induce ADCC,
  • Easy- NO Cell culturing isrequired
  • Flexible– Effector cells, which can be used with any Target cell, include a normalization readout which can adjust for differences in cell counts.
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EagleBio’s ACTH ELISA Used in Canadian Study

by Eagle Biosciences

 

ACTH ELISA was recently utilized in a Canadian Study. ACTH ELISA is part of
our Steroid Assay Kit Line ,
a product linewhich offers an array of interesting and sensitive
assays for different hormone analytes and research needs. Check the product
page for full details on the kit or view the links below to find a new
publication referencing our ACTH ELISA.

F.O.
Owagboriaye, et. al. Assessment of the effect of gasoline fume on stress
hormones, antioxidant status and lipid peroxidation in albino rat, Journal of
King Saud University – Science, Available online 2 December 2016, ISSN
1018-3647, https://dx.doi.org/10.1016/j.jksus.2016.11.002.

Publication Highlights:

“Gasoline fume has been considered a major air
pollutant affecting the heart, lungs, brain, liver and kidneys. Therefore, this
study aims at investigating the effect of inhalation exposure to gasoline fume
on some endogenic stress hormones and oxidative enzymes of albino rats……The
levels of adrenocorticotropic hormone (ACTH), aldosterone and corticosterone
were determined using enzyme-linked immunosorbent assay (ELISA) kits.” 

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Product Highlights: Chromogranin A ELISA

by Eagle Biosciences

Chromogranin A ELISA

Chromogranin A ELISA is for Research Use Only.

Eagle Biosciences’ Chromogranin A ELISA in our Cancer Biomarker Assay Kit Line. The Cancer Biomarker Assay Kit Line offered Eagle Biosciences provides a comprehensive array of sensitive and valuable tools to assist researchers in new emerging market segments in cancer research such as tumor marker and antitumor therapy investigation.

Our Chromogranin A ELISA is one of the unique assays in the this Cancer Biomarker Assay Kit Line that offers excellent  sensitivity, precise results in under 3 hours, and exclusive measurement of human chromogranin A without the high dose “hook” effect up to 1,000,000 ng/ml.

Why Measure Chromogranin A?

Chromogranin A (CgA) is a 49 kDa acidic protein that consists of 439 amino acids encoded on chromosome 14. It has been identified in a number of normal and neoplastic endocrine tissues. In fact, chromogranin A is a highly sensitive and specific marker for pheochromocytoma, carcinoids, and other neuroendocrine tumors (NET) [1]. Molina et. al describes “CgA is one of the most used tumor markers in NETs, and elevated CgA concentrations have been demonstrated in serum or plasma of patients with different types of these tumors [2].”

The measurement of Chromogranin A  provides incredible value to scientists studying numerous areas of cancer research beyond other biomarkers utilized for the detection, evaluation, and monitoring of specific tumor types.

Key Advantages of EagleBio’s Chromogranin ELISA, CHR31-K01

  • Excellent Sensitivity
  • Precise results under 3 hours
  • Measures CgA without the high dose “hook” effect up to 1,000,000 ng/ml.
  • Competitive Price

Recent Citations for EagleBio’s Chromogranin A ELISA

Conteduca et. al. Chromogranin A is a Potential Prognostic Marker in Prostate Cancer Patients Treated With Enzalutamide. Prostate. 2014 Dec;74(16):1691-6. PMID: 25262981.

Molina et al. Evaluation of chromogranin A determined by three different procedures in patients with benign diseases, neuroendocrine tumors and other malignancies. Tumor Biol. (2011) 32:13–2. PMID:20730520

Burgio SL.et. al. Chromogranin A predicts outcome in
prostate cancer patients treated
with abiraterone. Endocr Relat Cancer. 2014 May 8;21(3):487-93.  PMID: 24741024

 

References:

1. Pirker RA et. al, Usefulness of chromogranin A as a marker for detection of relapses of carcinoid tumours. Clin Chem Lab Med. 1998 Nov;36(11):837-40. PMID: 9877088

2. Molina et al. Evaluation of chromogranin A determined by three different procedures in patients with benign diseases, neuroendocrine tumors and other malignancies. Tumor Biol. (2011) 32:13–2. PMID:20730520

 

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EagleBio’s Serotonin ELISA Cited in a Michigan State University Study

by Eagle Biosciences

EagleBio’s Serotonin ELISA was used in a Michigan State Univeristy study (see citation below).  This is a kit from our Neurobiology Assay Kit line. The Neurobiology Assay Kit line offered Eagle Biosciences provides a comprehensive array of sensitive tools to measure catecholamines and numerous neuroscience-related analytes on various types of samples.

Plasma serotonin levels were determined in this study using Eagle Biosciences’ Serotoinin ELISA:

Joshi, N. Inhibition of PAR-4 and P2Y12 receptor-mediated platelet activation produces distinct hepatic pathologies in experimental xenobiotic-induced cholestatic liver disease. Toxicology. 2016; 365:9-16.

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Product Hightlights: Periostin ELISA Assay Kit

by Eagle Biosciences

 

Periostin ELISA is designed for the quantitative determination of human Periostin in serum and plasma and is for Research Use Only. This assay is part of Eagle Biosciences’ Bone Metabolism Line which is a comprehensive portfolio of assays for detecting and monitoring numerous biomarkers for the regulation of bone and mineral homeostasis, assisting researchers in various fields of study.

Highlights

• Extensively validated
• 7 human serum based standards and 2 controls
• CE registration in progress

Related Areas of  Research: 

Osteology, tissue repair, cardiovascular disease, oncology, respiratory disease

Learn More

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Metformin Plus Syrosingopine Effectively Combats Cancer Cells

by Eagle Biosciences
Metformin Plus Syrosingopine Effectively Combats Cancer Cells

Bengtsson, M.  Metformin Plus Syrosingopine Effectively Combats Cancer Cells. December 27, 2016 Retrieved from: www.reliawire.com.

“A combination of a diabetes medication and an antihypertensive drug effectively fights cancer cells, according to a team of researchers at the University of Basel. They also report that specific cancer cells respond to this combination of drugs.”   Read More


Source: (https://reliawire.com/metformin-syrosingopine-cancer/)




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EagleBio’s New Drug Monitoring Assays

by Eagle Biosciences

 Assays below are For Research Use Only.

EagleBio’s New Drug Monitoring Assays:

Eagle Biosciences is pleased to offer 3 new assays to the Drug Monitoring Assay Kit line which offers a unique grouping of products that provide incredible value to pre-clinical and clinical pharmacology studies, cancer research, and more specifically antitumor therapeutic investigation and more.

      • NF alpha Neutralization Rate/Adalimumab ELISA Assay Kit
        • Simultaneously determination:

          • Free TNFα target antigen
          • Available therapeutic antibody Adalimumab
          • Adalimumab’s ability to neutralize TNFα
      • TNF alpha Neutralization Rate/Infliximab ELISA Assay Kit:
        •  Simultaneously determination:
          • Free TNFα target antigen
          • Available therapeutic antibody Infliximab
          • Infliximab’s ability to neutralise TNFα
      • Deoxynivalenol ELISA Assay Kit
        • Unique Assay for Determination:
          • Deoxynivalenol in food and feed crops
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Washington Study Uses Eagle Biosciences’ Biotinlylated Insulin

by Eagle Biosciences
Washington Study Uses Eagle Biosciences’ Biotinlylated Insulin

 

 

EagleBio’s Human Insulin, Biotinylated (Biotin-Insulin) was recently utilized in a Washington State University Study. This recombinant human insulin is a part of our Endocrine product line that offers a comprehensive product grouping of unique for measuring a variety of analytes for diabetes and obesity research.

Citation:

Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites

“Autoantibodies to insulin are a harbinger of autoimmunity in type 1 diabetes in humans and in non-obese diabetic mice. To understand the genesis of these autoantibodies, we investigated the interactions of insulin-specific T and B lymphocytes using T cell and B cell receptor transgenic mice.”

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Anti-Inflammatory Drugs Might Someday Treat Depression

by Eagle Biosciences

Kappelmann, N. et al. Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions. Molecular Psychiatry.2016 00, 1–9. https://dx.doi.org/10.1038/mp.2016.167

“In the future, a new class of anti-inflammatory drugs could be used to treat depression, say University of Cambridge researchers.

Drugs such as aspirin and ibuprofen treat inflammation, the body’s immune response to infections or pathogens. During an inflammatory response, immune cells flood the bloodstream with proteins known as cytokines.” Read More

Source: (https://edition.cnn.com/2016/10/18/health/anti-inflammatory-drugs-depression)