Ubiquinone Coenzyme Q10 HPLC Assay
The Ubiquinone Coenzyme Q10 HPLC Assay is For Research Use Only
Size: 100 tests
Incubation Time: 10 minutes
Sample Type: Serum, Plasma, EDTA Blood
Sample Size: 200 µL
Reference Values (Normal):
- EDTA-plasma: 0.8 – 1.4 µg/ml (Mortensen S. A. et al: (1997) Molec.Aspects Med. 18:137-144)
Developed and Manufactured in Germany
Product Support in USA
It is suggested that each laboratory establish its own normal ranges
Ubiquinone is a coenzyme of every cell in the body. It was first isolated in the 50th from Prof. Green from Wisconsin. For his investigations concerning the function Prof. Mitchel received 1978 the Nobel price. Ubiquinone is built up by a chinonic ring and an isoprenic sidechain. In humans ubiquinone can be synthesized and taken up by nutrition. Ubiquinone has two different pysiological functions.
1.) Component of the energy metabolism
During the reduction of oxygen in the oxydative phosphorylation electrons are tranferred from NADPH to oxygen via 6 different redox systems. Ubiquinone is the less abundant redox system in the membrane of the mitochondria. Because of the low amount it is the speed controlling redox-system in the energy metabolism. Normally the amount of ubiquinone is sufficient, but with growing age and exposure to sunlight it is reduced to 50 %.
2.) Radical scavanger
Ubiquinone has a high amount of carbon doublebonds and therefore a higher potential of reduction than vitamin C or vitamin E. Thereby it is the first line of defense against free radicals. Even when other antioxidants are inert coenzyme Q10 reacts fast and sensitive against free radicals. Therefore ubiquinone is an optimal stabilizer of the ion channels of the membranes.