Ubiquinone Coenzyme Q10 HPLC Column
The Ubiquinone Coenzyme Q10 HPLC Column is For Research Use Only
Each column is can be utilized for approximately 500-1000 samples depending on column care and sample type.
Assay Background
Ubiquinone is a coenzyme of every cell in the body. It was first isolated in the 50th from Prof. Green from Wisconsin. For his investigations concerning the function Prof. Mitchel received 1978 the Nobel price. Ubiquinone is built up by a chinonic ring and an isoprenic sidechain. In humans ubiquinone can be synthesized and taken up by nutrition. Ubiquinone has two different physiological functions.
1.) Component of the energy metabolism
During the reduction of oxygen in the oxydative phosphorylation electrons are tranferred from NADPH to oxygen via 6 different redox systems. Ubiquinone is the less abundant redox system in the membrane of the mitochondria. Because of the low amount it is the speed controlling redox-system in the energy metabolism. Normally the amount of ubiquinone is sufficient, but with growing age and exposure to sunlight it is reduced to 50 %.
2.) Radical scavanger
Ubiquinone has a high amount of carbon double bonds and therefore a higher potential of reduction than vitamin C or vitamin E. Thereby it is the first line of defense against free radicals. Even when other antioxidants are inert coenzyme Q10 reacts fast and sensitive against free radicals. Therefore ubiquinone is an optimal stabilizer of the ion channels of the membranes.
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