Rat Prorenin & Renin ELISA Assay
The Rat Prorenin & Renin ELISA Assay is For Research Use Only
Size: 1×96 wells
Sensitivity: 0.1 ng/mL
Dynamic Range: 0.1 – 100 ng/mL
Incubation Time: 1.5 hour
Sample Type: Biological Fluids
Sample Size: 100 µl
Product manufactured in the USA
Reference Values (Normal)
Rat prorenin levels range from 0-400 ng/ml depending on assay methodology. Human plasma levels of prorenin are greater in males than females and correlate positively with age and negatively with blood pressure. Plasma and serum concentrations increase in several conditions such as pregnancy, progressive diabetes mellitus, diabetes mellitus with microvascular disease, and diabetic retinopathy.
It is suggested that each laboratory establish its own normal ranges.
Prorenin is a glycosylated aspartic protease that consists of 2 homologous lobes and is the precursor of renin. Renin activates the renin-angiotensin system by cleaving angiotensinogen, produced by the liver, to yield angiotensin I, which is further converted into angiotensin II by ACE, the angiotensin-converting enzyme primarily within the capillaries of the lungs. It has been reported that the levels of circulating prorenin (but not renin) are increased in diabetic subjects.