MASP-2 ELISA Assay Kit
The MASP-2 ELISA Assay Kit is For Research Use Only
Sizes: 1 x 96 wells
Sensitivity: 1.6 ng/mL
Dynamic Range: 1.6 – 100 ng/mL
Sample Size: 100 uL
Incubation Time: 3 hours 30 minutes
Sample Type: Serum, Plasma, Cell Culture Supernatant
Controls Not Included
Assay Background
MASP-2 is a MBL associated serine protease. Mannan-binding lectin (MBL) and ficolins, in
complex with MASPs, are capable of activating the complement system, thus mediating the destruction of infectious agents. After oligomerisation of MBL (or L-Ficolin) MASP-2 will be bound and activated. Activated MASP-2 cleaves C4 and C2 and is crucial for the activation of downstream complement components. MASP-2 deficiency will result in an increased susceptibility for infections (e.g. leukemia patients in chemotherapy are at high risk of serious infections). Even more so than MBL deficiency, because MASP-2 is also required for complement activation by H- and L-ficolin. The ELISA detects MASP-2 in serum and plasma. The MASP-2 levels in plasma from healthy individuals range from 170 to 1196 ng/ml.
Please notice there is no guarantee for any batch-to-batch variability for this specific kit. We advise to use the same lot number if multiple kits are needed for a larger project. For more information or larger quantities please contact us at info@eaglebio.com.
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