Lactoferrin ELISA Assay Kit
Lactoferrin ELISA Assay Kit manufactured in Germany by Immundiagnostik
Size: 1×96 wells
Sensitivity: 0.369 ng/mL
Incubation Time: 1.5 hours
Sample Type: Stool
Sample Size: 15 mg
Alternative Names: Human Lactoferrin ELISA
For Research Use Only
Lactoferrin is a 76 kDa iron-binding glycoprotein which is synthesised and stored in the secondary granules of neutrophils. It is also present in several secretory fluids, such as milk, saliva, tears, and nasal secretions. Lactoferrin can exist in different polymeric forms ranging from monomers to tetramers; it tends to polymerise especially at high concentrations.
The physiological activities of lactoferrin include regulation of iron homeostasis, innate defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis.
During intestinal inflammation, polymorphonuclear neutrophils infiltrate the mucosa and release lactoferrin by degranulation, which results in an increased excretion of lactoferrin into the faeces. Faecal lactoferrin is therefore a marker for neutrophilic intestinal inflammation.
- Detection of intestinal inflammatory activity
- Monitoring of disease activity in inflammatory bowel disease (IBD)
- Prediction of relapse of IBD
- Assessment of IBD treatment response
Quality Control and Reference Range:
We recommend the use of external controls for internal quality control, if possible. Control samples should be analysed with each run. Results, generated from the analysis of control samples, should be evaluated for acceptability using appropriate statistical methods. The results for the patient samples may not be valid if within the same assay one or more values of the quality control sample are outside the acceptable limits.
We recommend each laboratory to establish its own reference concentration range.
Reference values in stool: 1g stool is equivalent to 1ml.
Normal value: <7,2µg/ml