Human TRAIL R1 ELISA Assay
The Human TRAIL R1 ELISA Assay is For Research Use Only
Size: 1×96 wells
Sensitivity: 8 ng/ml
Dynamic Range: 31.25 – 1000 ng/ml
Incubation Time: 2h 30 min
Sample Type: Serum, Cell Lysates, Cell Culture
Sample Size: 100 µl
Alternative Names: CD261, DR4, Death Receptor 4, APO2 ligand Receptor 1, Tumor necrosis factor-related apoptosis-inducing ligand receptor 1
Human TRAIL R1/DR4, CD261 or DR4 (Death Receptor 4) is a TNF receptor, which is a receptor for TRAIL (APO2 ligand). TRAIL R1 is involved in apoptosis. In the TRAIL receptor family, TRAIL R1, but also TRAIL R2 (DR5) transduce an apoptosis signal, whereas TRAIL R3 (DcR1) and TRAIL R4 (DcR2) antagonize TRAIL-induced apoptosis. Binding of trimeric TRAIL to TRAIL R1 induces apoptosis by oligomerization (likely to be trimerization) of the receptor. TRAIL R1 cDNA encodes a 468 amino acid residue precursor protein containing extracellular cysteine-rich domains, a transmembrane domain and a cytoplasmic death domain. TRAIL R1 shares 55% of its amino acid sequence with TRAIL R2. TRAIL R1 is widely expressed in normal tissue.
Store the Human TRAIL/R1/DR4 ELISA Assay kit reagents between 2 and 8°C. Immediately after use remaining reagents should be returned to cold storage (2-8°C). Expiry of the kit and reagents is stated on box front labels. The expiry of the Human TRAIL/R1/DR4 ELISA Assay kit components can only be guaranteed if the components are stored properly, and if, in case of repeated use of one component, the reagent is not contaminated by the first handling.