Human Recombinant Transthyretin Y78F Variant Protein Filaments
For Research Use Only
Specificity: 15.887 kDa
Expression System: E. coli
Buffer: PBS pH 7.4
Storage Temperature: -80ºC
Product manufactured in Canada by StressMarq.
Transthyretin is a transport protein in the serum and cerebospinal fluid that carried the thyroid hormone Thyroxine and retinol-binding protein bound to retinol. TTR misfolding and aggregation is known to be associated with the amyloiddiseases SSA, FAP and FAC (1-5). TTR is also thought to have beneficial side effects, such as binding to beta-amyloid protein, preventing beta-amyloid from accumulating into the plaques associated with Alzheimer’s Disease (6). The mutant variant Y78F indicates a destabilization of the contacts between the alpha-helix and AB loop and the body of the molecule, potentially leading to applications in immne therapy for FAP (7).