Human Recombinant Transthyretin Y78F Variant Protein Filaments
For Research Use Only
Specificity: 15.887 kDa
Species: Human
Expression System: E. coli
Buffer: PBS pH 7.4
Storage Temperature: -80ºC
Product manufactured in Canada by StressMarq.
Human Recombinant Transthyretin Y78F Variant Protein Filaments
$535.00 – $1,660.00
Turbidity Assay shows increased turbidity in Human Recombinant Transthyretin Y78F Variant Protein Filaments. This product is for research use only and not for use in diagnostic procedures.
Additional Information
Scientific Background
Transthyretin is a transport protein in the serum and cerebospinal fluid that carried the thyroid hormone Thyroxine and retinol-binding protein bound to retinol. TTR misfolding and aggregation is known to be associated with the amyloiddiseases SSA, FAP and FAC (1-5). TTR is also thought to have beneficial side effects, such as binding to beta-amyloid protein, preventing beta-amyloid from accumulating into the plaques associated with Alzheimer’s Disease (6). The mutant variant Y78F indicates a destabilization of the contacts between the alpha-helix and AB loop and the body of the molecule, potentially leading to applications in immne therapy for FAP (7).
