Human Recombinant Transthyretin L55P Variant Protein Filaments
For Research Use Only
Specificity: 15.887 kDa
Expression System: E. coli
Buffer: PBS pH 7.4
Storage Temperature: -80ºC
Product manufactured in Canada by StressMarq.
Transthyretin is a transport protein in the serum and cerebospinal fluid that carried the thyroid hormone Thyroxine and retinol-binding protein bound to retinol. TTR misfolding and aggregation is known to be associated with the amyloiddiseases SSA, FAP and FAC (1-5). TTR is also thought to have beneficial side effects, such as binding to beta-amyloid protein, preventing beta-amyloid from accumulating into the plaques associated with Alzheimer’s Disease (6). The L55P variant TTR can dissociate to the monomeric amyloidogenic intermediate and form fibril precursors (7).