Human Recombinant Tau dGAE (297-391) Monomers


The Human Recombinant Tau dGAE (297-391) Monomer is intended for research use only and not for use in diagnostic or clinical procedures. Contact us for bulk pricing.

SKU: SPR-501B Categories: , ,

Human Recombinant Tau dGAE (297-391) Monomers

The Human Recombinant Tau dGAE (297-391) Monomers are For Research Use Only

Specificity: N/A
Species: Human
Expression System: E. coli
Buffer: 10mM PB pH 7.4, 10mM DTT
Storage Temperature: -80ºC
Alternative Names: Tau monomer, Tau protein monomer, Tau protein, microtubule-associated protein Tau, MAPT, MAP, microtubule-associated protein, Truncated Tau Protein Monomer, Paired Helical Filament-Tau, Phf-Tau, Neurofibrillary Tangle Protein, Tau dGAE Protein, dGAE

Product manufactured in Canada by StressMarq.

Scientific Background

Filamentous tau inclusions are a hallmark of many neurodegenerative diseases, including Alzheimer’s disease (AD) and Chronic Traumatic Encephalopathy (CTE), collectively called tauopathies. Advances in Cryo-EM have revealed that tau filaments isolated from individuals with a particular neurodegenerative disease share a distinct tau fold – i.e. an AD-isolated Tau filaments’ fold is distinct from a CTE-isolated Tau filaments’ fold. Utilizing Tau filaments with the correct disease-specific fold is an important goal towards better mimicking specific human diseases in cellular and in vivo models. Recent Cryo-EM studies have demonstrated that recombinantly generated Tau dGAE monomers will form the disease-isolated AD or CTE Tau filament folds under highly specific conditions in vitro. Eagle Biosciences SPR-501 Tau (297-391) dGAE monomers are purified following these exact published procedures and can be utilized to form these distinct folds using specific aggregation conditions.

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Package Inserts

Please note: All documents above are for reference use only and should not be used in place of the documents included with this physical product. If digital copies are needed, please contact us.

Product Citations