Active Human Recombinant Tau (K18) K280 Deletion Protein Pre-formed Fibrils
The Active Human Recombinant Tau (K18) K280 Deletion Protein Pre-formed Fibrils are For Research Use Only
Expression System: E. coli
Buffer: PBS pH 7.4
Storage Temperature: -80ºC
Alternative Names: Active tau PFFs, active tau protein preformed fibrils, active tau aggregates, microtubule-associated protein tau, MAPT, MAP, microtubule-associated protein, Paired Helical Filament-Tau, Phf-Tau, Neurofibrillary Tangle Protein, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Isoform 4, tubulin-associated unit, MAPT DeltaK280, K280 deletion tau, K18 delta K280 tau, truncated delta K280 tau
Product manufactured in Canada by StressMarq.
Alzheimer’s Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils (3). The K280 deletion mutation is associated with frontotemporal dementia and promotes fibrillization into paired helical laments (PHFs) in the absence of heparin and other inducers (4). K18 is a truncated form of human tau containing only the 4 microtubule binding repeats (5).