Human (Leu27) IGF-II
$180.00
The Eagle Bioscience’s Human [Leu27] IGF-II is for research use only and not to be used in diagnostic procedures.
Human (Leu27) IGF-II
The Eagle Bioscience’s Human (Leu27) IGF-II is for research use only and not to be used for diagnostic procedures.
Product Specifications
Source:
IGF-II is produced in E.coli using a patented expression system.
Description:
Human (Leu27) insulin-like Growth Factor-II ([Leu27] IGF-II) is an analogue of human IGF-II which has a Leucine substitution in place of Tyrosine at position 27 of the human IGF-II sequence. (Leu27) IGF-II has normal binding to acid-stripped human serum binding proteins but has a 10-20 fold reduction in binding to the type 1 IGF receptor compared to IGF-II. It is a useful analogue for studying the effects of IGF-II through non-type 1 receptor binding mechanisms.
- Purity: >90 % (as determined by HPLC analysis)
- Quantity: 100 µg
- Molecular Weight: 7420 daltons – confirmed by Mass Spectrometry
- N-terminal sequence analysis of recombinant product: Analysis of 5 residues
- Biological Activity: IGF type 1 receptor binding assay (ED50 > 175 ng/ml) IGF type 2 receptor binding assay (ED50 < 370 ng/ml) IGF binding protein assay: ED50 < 10 ng/ml)
- Endotoxin (LAL): <0.1 EU/ug
- Storage/Stability: At least 2 years at 2-4°C (lyophilized)
- Appearance: White Powder
- State: Dried from 0.1 M acetic acid under dry nitrogen at a slight vacuum (-25kPa)
Related Products
IGF-II ELISA Assay Kit
Human Biotin Pro IGF-2
Biotinylated Human Des IGF-2
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Documents
Product Manual
Please note: All documents above are for reference use only and should not be used in place of the documents included with this physical product. If digital copies are needed, please contact us.
