Human CD213-alpha 2 ELISA Assay
The Human CD213-alpha 2 ELISA Assay is For Research Use Only
Size: 1×96 wells
Sensitivity: 150 pg/ml
Dynamic Range: 156 pg/ml – 5000 pg/ml
Incubation Time: 3h 45 min
Sample Type: Serum, Plasma, Cell Culture
Sample Size: 100 µl
Alternative Name: IL-13R alpha 2, CD213a, IL-13Ra2
Two membrane proteins belonging to the receptor family CD213a have been identified and shown to bind IL-13 with differing affinities and different functionality.
The CD213a2 also named IL-13 R alpha 2 binds, as monomer, IL-13 with high-affinity but not IL-4. The role of IL-13 R alpha 2 in IL-13 signaling remains to be elucidated. With a small 17 aa cytoplasmic domain, unable to induce signal, it does not appear to function as a signal mediator. It could act as a decoy receptor by binding and internalizing IL‑13 and preventing it from signaling through the IL‑13 R alpha 1/IL‑4 R alpha complex
The up‑regulation of transmembrane CD213a2 during Th2‑based immune responses limits the extent of those responses. IL-13Rα2 has been found to be over-expressed also in a variety of cancers, including pancreatic, ovarian, melanomas, and malignant gliomas.