Anti-SARS-CoV-2 Spike S1 Protein


Anti-SARS-CoV-2 Spike S1 Protein

The Anti-SARS-CoV-2 Spike S1 Protein is For Research Use Only

Target Species: SARS-CoV-2
Host Species: Human
Conjugate: Azide Free
Type: Monoclonal Antibody
Specificity: S1 domain of the SARS-CoV Spike protein (aa318-510) as well as SARS-CoV-2 (COVID-19) Spike protein
Application: ELISA
Hybridoma: Phage display library
Clone: CR3022
Immunisation: Generated by sequencing peripheral blood lymphocytes of a patient exposed to the SARS-CoV.
Isotype: Human IgG1 Kappa light chain
Format: Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free
Storage: Stable at +2-8°C for 12 months
Alternative Names: Receptor binding domain Spike protein, RBD spike protein

Product Background

Coronaviruses are positive-sense RNA viruses having an extensive range of natural hosts and typically affect the respiratory system. SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2) has four structural proteins, known as the S (spike), E (envelope), M (membrane), and N (nucleocapsid) proteins; the N protein holds the RNA genome, and the S, E, and M proteins together create the viral envelope. The S protein is a large viral transmembrane protein associated in a trimer manner on the virion surface, giving the virion a corona or crown-like appearance. Functionally it is the protein responsible for allowing the virus to attach to and fuse with the membrane of a host cell via the ACE2 protein. The ectodomains in all CoVs S proteins have similar domain organizations, divided into two subunits: the first one, S1, helps in host receptor binding, while the second one, S2, accounts for fusion. It also acts as a critical factor for tissue tropism and the determination of host range. The S protein is one of the proteins of CoVs capable of inducing most important host immune responses.

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