Anti-Denosumab ELISA Assay Kit
The Anti-Denosumab ELISA Assay Kit is For Research Use Only
Size: 12×8 wells
Sensitivity: <10 ng/ml
Standard Range: 10-640 ng/ml
Incubation Time: 2.25 hours
Sample Type: Serum, Plasma, Cell Culture Supernatants
Sample Size: 100 µl
Alternative Name: Prolia, Xgeva
Assay Background
Denosumab (trade names Prolia and Xgeva) is a human monoclonal antibody for the treatment of osteoporosis, treatment-induced bone loss, metastases to bone and giant cell tumor of bone.Denosumab is contraindicated in people with low blood calcium levels.The most common side effects are joint and muscle pain in the arms or legs.Denosumab is a RANKL inhibitor which works by preventing the development of osteoclasts which are cells that break down bone (bone resorption). Anti-Drug Antibodies (ADA) may induce unwanted side effects in biopharmaceuticals. Hence, ADA has been subjected to increase in scrutiny by the regulatory authorities using immunogenicity safety studies. ADA has been observed in pre-clinical and clinical studies, resulting in significant changes in toxicology, pharmacokinetics and efficacy. These effects result from the generation of drug-induced (neutralizing) autoantibodies against Denosumab and can be responsible for allergic reaction, or even anaphylactic shock. This ELISA kit detects antibodies for Anti-Denosumab and may be used for monitoring immunogenicity.
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