Amyloid Beta Peptide 1-42 (HFIP treated)


The Eagle Bioscience’s Amyloid Beta Peptide 1-42 (HFIP treated) is for research use only and not to be used for diagnostic procedures. Contact us for bulk pricing.

SKU: SPR-485B Categories: ,

Amyloid Beta Peptide 1-42 (HFIP treated)

The Amyloid Beta Peptide 1-42 (HFIP treated, monomeric) is For Research Use Only

Sizes: 100 µg, 1 x 500 µg, 1 x 1mg

Biological Description

Alternative Names: Abeta Protein, Abeta peptide, Amyloid beta peptide, Beta amyloid peptide, amyloid beta precursor protein peptide, APP

Research Areas: Alzheimer’s Disease, Amyloid, Neurodegeneration, Neuroscience

Cellular Localization: Cell membrane, Intracellular Vesicles

Sequence References: Gene ID: 351; Swiss Prot: P05067

Function: Our amyloid beta peptide 1-42 (Aβ42) is produced synthetically and treated with 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) prior to drying which breaks down pre-formed fibrils and monomerizes the peptide, as previously published. Upon resuspension in DMSO/dH2O, our Aβ42 presents as a monomeric peptide without fibrils when observed under TEM, AFM and on a Western Blot with an anti-amyloid beta antibody. In contrast to AB42 oligomer and fibril constructs, our Aβ42 monomers were not toxic to primary rat cortical neurons. In the brain, amyloid beta peptide (Aβ) is generated by protease cleavage of amyloid precursor protein (APP), which aggregates into oligomers, protofibrils, fibrils and ultimately plaques in neurodegenerative diseases. The accumulation of Aβ plaques in the brain is considered a hallmark of Alzheimer’s disease (AD), and most of the drugs tested for AD in the past 20 years have targeted amyloid beta accumulation. Soluble Aβ oligomers isolated from the brains of AD patients or those generated in vitro potently impaired synapse structure and function. Aβ oligomers generated in vitro were toxic to PC12 cells and SH-SY5Y cells. Aβ was demonstrated to interact with tauopathies to affect neurodegeneration in AD patients and accumulations of Aβ were shown to be associated with lower survival rates in Parkinson’s disease patients with dementia.

Related Products:

Rodent beta Amyloid 1-42 ELISA
Rodent beta Amyloid 1-40 ELISA
Rodent beta-Amyloid 1-42 Plasma ELISA


Product Manual

Please note: All documents above are for reference use only and should not be used in place of the documents included with this physical product. If digital copies are needed, please contact us.

Product Citations