Alpha Synuclein S87N Mutant Pre-formed Fibrils
Alpha Synuclein S87N Mutant Pre-formed Fibrils are For Research Use Only
Size: 100 ug
Species: Human
Expression System: E. coli
Buffer: 1X PBS pH 7.4
Storage Temperature: -80ºC
Alternative Names: Alpha synuclein protein, Alpha-synuclein protein, Non-A beta component of AD amyloid protein, Non-A4 component of amyloid precursor protein, NACP protein, SNCA protein, NACP protein, PARK1 protein, SYN protein, Parkinson’s disease familial 1 Protein, Alpha Synuclein TNG
Research Areas:: Alzheimer’s Disease, Neurodegeneration, Neuroscience, Parkinson’s Disease, Synuclein, Tangles & Tau, Multiple System Atrophy
Product manufactured in Canada by StressMarq.
Scientific Background
Human alpha synuclein S87N mutant (HuS87N) has Ser87 mutated to the equivalent mouse residue Asn87,effectively making it a human-mouse chimeric protein. Despite sequence differences at only seven residues, or 5% of the total 140 amino acids, the aggregation rate of wild-type mouse α-syn (MsWT) is faster than wild-type human α-syn (HuWT) in vitro. In wild-type mouse models, MsWT fibrils are more efficient than HuWT fibrils at inducing endogenous mouse α-syn pathology. A53T or S87N substitutions in human α-syn substantially accelerate fibrilization rates in vitro. Chimeric HuS87N fibrils show enhanced induction of α-syn pathology greater than both HuWT and MsWT fibrils in mice neuron cultures. Therefore, HuS87N is a good construct for inducing robust endogenous α-syn seeding and pathology in wild-type mice/cultures.
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