Active Recombinant Tau441 (2N4R), P301S Mutant Protein Monomer
The Active Recombinant Tau441 (2N4R), P301S Mutant Protein Monomer is For Research Use Only
Specificity: N/A
Species: Mouse
Expression System: E. coli
Buffer: PBS pH 7.4
Storage Temperature: -80ºC
Alternative Names: Active tau monomer, active tau protein monomer, active tau protein, microtubule-associated protein tau, MAPT, MAP, microtubule-associated protein, tau-441, Paired Helical Filament-Tau, Phf-Tau, Neurofibrillary Tangle Protein, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Isoform 2, tubulin-associated unit, P301S mutant tau, 2N4R tau, mouse tau protein
Product manufactured in Canada by StressMarq.
Scientific Background
Alzheimer’s Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils (3). 2N4R, or Tau-441 is the full length tau protein. P301S is a mutation encoded by exon 10 (4) that impairs the ability of tau to assemble microtubules (5).
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