Amyloid Beta Pyroglutamate 3-42 Pre-Formed Fibrils (PFFs)
Amyloid Beta Pyroglutamate 3-42 Pre-Formed Fibrils are For Research Use Only
Size: 100 ug
Species: Human
Buffer: 10 mM HCl with 2% DMSO
Storage Temperature: -80ºC
Alternative Names: pyro abeta, pyro amyloid beta, Abeta, Amyloid beta peptide, Beta amyloid peptide, amyloid beta precursor protein peptide, pyroglutamate amyloid beta, APP
Research Areas:: Alzheimer’s Disease, Amyloid, Neurodegeneration, Neuroscience
Product manufactured in Canada by StressMarq.
Scientific Background
Our Amyloid Beta pyroglutamate 3-42 (pyro AB) Pre-formed Fibrils are generated from Amyloid Beta Peptide 3-42 pre-treated with 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) using a previously published method. Our pyro AB3-42 fibrils present as primarily long strands when observed under TEM and AFM, and have a unique high molecular weight signal on a Western Blot with an anti-amyloid beta antibody. Amyloid beta peptide (AB) is generated by protease cleavage of amyloid precursor protein (APP), which aggregates into oligomers, protofibrils, fibrils and ultimately plaques. The accumulation of AB plaques in the brain is considered a hallmark of Alzheimer’s disease (AD), and most of the drugs tested for AD in the past 20 years have targeted amyloid beta accumulation. Pyroglutamate AB 3-42 is an N-terminally truncated peptide species that is modified by glutaminyl cyclase and has been reported to compromise 15-45% of total amyloid beta deposits in brains of AD patients. Pyroglutamate AB 3-42 exhibits higher aggregation propensity and neurotoxicity compared with full-length AB 1-42 and is an active target in the next generation AD therapeutic development.
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