Active Human Recombinant Tau441 (2N4R) Wild-Type Protein Pre-formed Fibrils (PFFs)
The Active Human Recombinant Tau441 (2N4R) Wild-Type Protein Preformed Fibrils are For Research Use Only
Specificity: N/A
Species: Human
Expression System: E. coli
Buffer: 10 mM HEPES, 100 mM NaCl pH 7.4
Storage Temperature: -80ºC
Alternative Names: Active tau PFFs, active tau protein preformed fibrils, active tau aggregates, microtubule-associated protein tau, MAPT, MAP, microtubule-associated protein, Paired Helical Filament-Tau, Phf-Tau, Neurofibrillary Tangle Protein, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Isoform 4, tubulin-associated unit, MAPT DeltaK280, ΔK280 tau, K18 delta K280 tau, truncated ΔK280 tau
Product manufactured in Canada by StressMarq.
Scientific Background
Alzheimer’s Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils (3). The ΔK280 mutation is associated with frontotemporal dementia and promotes fibrillization into paired helical filaments (PHFs) in the absence of heparin and other inducers (4). K18 is a truncated form of human tau containing only the 4 microtubule binding repeats (5).
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