Kryptopyrrol ELISA Assay Kit
Kryptopyrrol ELISA Assay Kit manufactured in Germany by Immundiagnostik
Size: 40 tests
Incubation Time: 30 minutes
Sample Type: Urine
Sample Size: 2 ml
Alternative Names: Kryptopyrrole ELISA Assay Kit, Human Quantitative Urine Kryptopyrrol ELISA
For Research Use Only
Controls Included
Assay Background for Kryptopyrrol ELISA Kit
Kryptopyrroluria is a genetically determined enzymatic disorder of the hem metabolism, which is essentially compensated under normal conditions. However, under stress conditions, there is an insufficient compensation and the disorder is manifested in the form of several different disease symptoms. Kryptopyrroluria can be diagnosed with high reliability by detection of abnormal increased pyrrole excretion in urine. Kryptopyrrole, 2,4 dimethyl-3-ethylpyrrole, is a byproduct of disordered hemoglobin synthesis. It has been found out that circulating kryptopyrrole forms a Schiff’s base with the aldehyde group of pyridoxal-5’-phosphate (P-5-P), the active vitamin B6 form in the blood, whereby an additional zinc binding results in formation of an insoluble kryptopyrrole – zinc – vitamin B6 -complex. Elevated excretion of kryptopyrrole in the urine is associated with an enhanced vitamin B6 and zinc excretion and as a result in a B6 and zinc deficiency in the blood. Kryptopyrroluria is involved in behavior and emotional disorders. Increased kryptopyrrole values were found in children and juveniles with ADHS (Attention Deficit Hyperactivity Syndrome), as well as in children with disturbed short-term memory, learning difficulties, dyslexia and stress-intolerance. Positive therapy experiences were made with substitution of zinc, vitamin B6 and manganese.
Indications
• Behavior disorders
• Autism, Asperger´s
• ADHD, ADD
• Depression
• Bipolar disorders
• Assaultive/aggressive/violent behavior
• Schizophrenia
• Irritability
• Poor tolerance of physical and emotional stress
• Anger
• Episodes
• Poor memory
• Agitation
• Poor dream recall
• Sensitivity to light and sound
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