Tim-3 Recombinant Rabbit Monoclonal Antibody
The Tim-3 Recombinant Rabbit Monoclonal Antibody is for research use only
Clone #: BP6182
Form: Liquid
Predicted Molecular Weight: 33 kDa
Purity: ProA affinity purified IgG
Species Cross-reactivity: Human
Applications: IHC-P
Background:
T cell Ig- and mucin-domain-containing molecules (TIMs) area family of transmembrane proteins expressed by various immune cells. TIM-3 is expressed by exhausted T cells in the settings of chronic infection and cancer, and tumor-infiltrating T cells that coexpress PD-1 and TIM-3 exhibit the most severe exhausted phenotype. TIM-3 is an inhibitory molecule that is induced following T cell activation. Tumor-infiltrating dendritic cells (DCs) also express TIM-3 . TIM-3 expression on DCs was found to suppress innate immunity by reducing the immunogenicity of nucleic acids released by dying tumor cells. Research studies show that heterodimerization of TIM-3 with CEACAM-1 is critical for the inhibitory function of TIM-3, and co-blockade of TIM-3 and CEACAM-1 enhanced antitumor responses in a mouse model of colorectal cancer. In addition, blockade of TIM-3 in mouse models of autoimmunity enhanced the severity of disease.
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