Tau441 2N4R P301S mutant PPFs ATTO 488

$550.00$1,725.00

The Tau441 2N4R P301S mutant PPFs ATTO 488 is intended for research use only and not for use in diagnostic or clinical procedures.

Clear
SKU: SPR-329-A488 Categories: , Tags: ,

Tau441 2N4R P301S mutant PPFs ATTO 488

The Tau441 2N4R P301S mutant PPFs ATTO 488 is For Research Use Only

Nature: Recombinant
Species: Human
Expression System: E. coli
Buffer: PBS pH7.4, 0.09% Azide
Storage Temperature: -80ºC
Alternative Names: Active tau PFFs, active tau protein preformed fibrils, active tau aggregates, microtubule-associated protein tau, MAPT, MAP, microtubule-associated protein, Paired Helical Filament-Tau, Phf-Tau, Neurofibrillary Tangle Protein, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Isoform 4, tubulin-associated unit, mouse tau protein, P301S mutant tau, 2N4R tau, Tau441, fluorescent tau fibrils, ATTO 488 conjugated tau, ATTO labelled tau fibrils

Product manufactured in Canada by StressMarq.


Assay Background

Alzheimer’s Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65. It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907. Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils. There are six isoforms of tau in the adult human brain: three with four repeat units (4R) and three with three repeat units (3R). 2N4R, or Tau-441 is the full length tau protein. P301S is a mutation encoded by exon 10 that impairs the ability of tau to assemble microtubules.


Related Products

Tau441 2N4R P301S mutant Protein Monomer
Tau441 (2N4R) mutant Protein Monomer
SNCA Protein Pre-formed Fibrils ATTO 594

Documents

Product Manual


Product Citations