Tau-441 (2N4R) Wild-Type Pre-formed Fibrils (Baculovirus/Sf9)


The Tau-441 (2N4R) Wild-Type Pre-formed fibrils (Baculovirus/Sf9) are for research use only and not to be used for diagnostic procedures. Contact us for bulk pricing.

SKU: SPR-498B Categories: ,

Tau-441 (2N4R) Wild-Type Pre-formed Fibrils (Baculovirus/Sf9)

Tau-441 (2N4R) Wild-Type Pre-formed Fibrils (Baculovirus/Sf9) are For Research Use Only

Size: 100 ug
Species: Human
Expression System: Baculovirus (Sf9)
Buffer: 1X PBS pH 7.4
Storage Temperature: -80ºC
Alternative Names: MAPT, intracellular neurofibrillary tangles, NFTs, paired helical filaments, PHFs, 2N4R
Research Areas:: Alzheimer’s Disease, Neurodegeneration, Neuroscience, Tangles & Tau

This product is manufactured in Canada by StressMarq.

Scientific Background

Brain-specific tau isoforms vary in the number of N-terminal inserts and C-terminal repeat domains due to alternative splicing of exons; the 2N4R isoform of tau is expressed in adult brain yet is absent from the fetal brain. Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilized microtubules. Tauopathies such as Alzheimer’s Disease (AD) are characterized by neurofibrillary tangles containing hyper-phosphorylated tau fibrils. Hyper-phosphorylated tau can be generated via expression in the Sf9/Baculovirus system, with up to 20 sites confirmed by mass spectrometry and Western Blots with phospho-specific antibodies. These Sf9/Baculovirus-expressed Tau 2N4R Pre-Formed Fibrils are generated without heparin.

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Product Manual

Please note: All documents above are for reference use only and should not be used in place of the documents included with this physical product. If digital copies are needed, please contact us.

Product Citations