Human Recombinant Tau-441 (2N4R) P301S Mutant Pre-formed Fibrils (CHO-expressed, N-glycosylated)
The Human Recombinant Tau-441 (2N4R) P301S Mutant Pre-formed Fibrils (CHO-expressed, N-glycosylated) are For Research Use Only
Size: 100 ug
Species: Human
Expression System: Chinese Hamster Ovary (CHO)
Buffer: 1X PBS pH7.4, 2mM DTT
Storage Temperature: -80ºC
Alternative Names: MAPT, intracellular neurofibrillary tangles, NFTs, paired helical filaments, PHFs, 2N4r
Product manufactured in Canada by StressMarq.
Scientific Background
Mammalian N-glycosylation is present on CHO-secreted tau 2N4R, which contributes to slower migration on SDS-PAGE than E.coli or Baculovirus/Sf9 expressed tau. N-glycosylated tau has been identified in human AD-disease brains, but not healthy brains, and may precede tau hyperphosphorylation. N-glycosylation of Tau has been demonstrated to affect its aggregation propensity. The tau P301S mutation is associated with early onset neurodegenerations, and functionally reduces microtubule assembly and stimulates fibril assembly. Our CHO-expressed Tau 2N4R P301S will readily form fibrils in the absence of heparin and contains mammalian post-translational modifications that may better mimic tau in human AD-brains.
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