sCD59 ELISA Assay Kit


The sCD59 ELISA Assay Kit is to be used for the in vitro quantitative determination of human sCD59 in plasma. The sCD59 ELISA Assay Kit is intended for laboratory research use only and is not for use in diagnostic or therapeutic procedures.

sCD59 ELISA Assay Kit

The sCD59 ELISA Assay Kit is For Research Use Only

Sizes: 1 x 96 wells
Sensitivity: 0.39 ng/mL
Dynamic Range: 0.39 – 25 ng/mL
Sample Size: 100 uL
Incubation Time: 3 hours 30 minutes
Sample Type: Plasma

Controls Not Included

Assay Background

CD59 is a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. Complement activation ultimately leads to formation of the cytotoxic, poreforming membrane attack complex (MAC), the main effector of complement-mediated tissue damage. Insertion of the MAC into cell membranes induces the release of cytokines and growth factors that promote inflammation, thrombosis, and cell proliferation. CD59 is a complement regulatory protein ubiquitously expressed on mammalian cell surfaces and it specifically inhibits MAC formation and thereby protects “self” cells from complement-mediated damage. The protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in the CD59 gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. CD59 was demonstrated to be present in plasma/serum of healthy individuals in levels ranging from 22 to 119 ng/ml.

Related Products

Rat Classical Complement Pathway ELISA Assay Kit
Mouse Classical Complement Pathway ELISA Assay Kit
Pig Lectin Complement Pathway ELISA Assay Kit
Pig Alternative Complement Pathway ELISA Assay Kit


Product Manual

Please note: All documents above are for reference use only and should not be used in place of the documents included with this physical product. If digital copies are needed, please contact us.

Product Citations