Neurofilament Mouse Monoclonal Antibody
The Neurofilament Mouse Monoclonal Antibody is for research use only
Clone #: BPM6226
Form: Liquid
Predicted Molecular Weight: 102 kDa
Purity: ProA affinity purified IgG
Species Cross-reactivity: Human
Applications: IHC-P
Background:
Neurofilaments are the major intermediate filaments found in neurons and consist of light (NFL), medium (NFM),and heavy (NFH) subunits. Similar in structure to other intermediate filament proteins, neurofilaments have a globular amino-terminal head, a central α-helical rod domain, and a carboxy-terminal tail. A heterotetrameric unit (NFL-NFM and NFL-NFH) forms a protofilament, with eight protofilaments comprising the typical 10 nm intermediate filament.
Research studies have shown neurofilament accumulations in many human neurological disorders including Parkinson’s disease (in Lewy bodies along with α-synuclein), Alzheimer’s disease, Charcot-Marie-Tooth disease, and Amyotrophic Lateral Sclerosis (ALS).
Neurofilament antibody mainly stains neurons in tissue sections of brain and other tissues. Neurofilament has been shown to react with neuroblastomas, gangliomas, pheochromocytomas, Merkel cell tumors and carcinoid tumors.
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