MSH6 Recombinant Rabbit Monoclonal Antibody
The MSH6 Recombinant Rabbit Monoclonal Antibody is for research use only
Clone #: BP6007
Form: Liquid
Predicted Molecular Weight: 153 kDa
Purity: ProA affinity purified IgG
Species Cross-reactivity: Human
Applications: IHC-P
Background:
MSH6 is a mismatch repair protein which is deficient in a high proportion of patients with microsatellite instability (MSI-H) . It has been suggested that the deficiencies in DNA mismatch repair protein(s) can be seen in some malignancies such as hereditary nonpolyposis colorectal cancer (HNPCC) and endometrial cancer.
MSH6 expressed in all proliferating cells participate in repair of base-base mismatch, that occur during DNA replication. Loss of MSH6 expression leads to an accumulation of DNA replication errors in the proliferating cells, particularly in areas of the genome with short repetitive nucleotide sequences, a phenomenon known as microsatellite instability (MSI).
MSH6 always used as panel with MLH1, MSH2, PMS2, and may be useful to aid in identifying the most probable gene responsible for the MSI.
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