Kynurenic Acid Polyclonal Antibody

$855.00

The Kynurenic Acid Polyclonal Antibody proved to work at 1/2000 dilution on paraffin-embedded tissues; (a single vial caters approximately 400 stainings). The Eagle Biosciences Kynurenic Acid Polyclonal Antibody is for research use only.

SKU: IS1011 Categories: ,

Kynurenic Acid Polyclonal Antibody

The Kynurenic Acid Polyclonal Antibody is For Research Use Only

Synonyms: Kynurenic acid polyclonal antibody, 4-Hydroxyquinoline-2-carboxylic acid polyclonal antibody, KYNA polyclonal antibody

Immunogen: Conjugated Kynurenic Acid

Specificity: When tested in competitive ELISA, the anti-Kynurenic polyclonal antibody did not show any significant cross reactivity with Quinaldic and Xanthurenic conjugates.

Size</strong: 50µl

Storage: 4°C
Storage buffer: Before use, vial should be resuspended in 50 µL of ultrapure water. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze / thaw cycles
Affinity & Specificity:
Competitive ELISA highlights that low amounts of conjugated Kynurenic acid are required to abolish antigen-antibody reaction (high affinity), while rising concentrations of analog conjugates (Quinaldic and Xanthurenic acid) affect only to a lesser extent the reaction (high specificity).


Kynurenic acid (KYNA) Background

L-tryptophan catabolism via the kynurenine pathway produces a range of neuroactive metabolites, including neurotoxic quinolinic acid and its neuroprotective counterpart: kynurenic acid. Known for its antagonistic activities on the NMDA receptor and the a7-nicotinic cholinoceptor (a7NR), Kynurenic acid has recently been described as an endogenous ligand of the orphan G-protein-coupled receptor GPR35.


Related Products

Quinolinic Acid Polyclonal Antibody
Anti-Conjugated Xanthurenic Acid Polyclonal Antibody

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