Kynurenic Acid Polyclonal Antibody
The Kynurenic Acid Polyclonal Antibody is For Research Use Only
Synonyms: Kynurenic acid polyclonal antibody, 4-Hydroxyquinoline-2-carboxylic acid polyclonal antibody, KYNA polyclonal antibody
Immunogen: Conjugated Kynurenic Acid
Specificity: When tested in competitive ELISA, the anti-Kynurenic polyclonal antibody did not show any significant cross reactivity with Quinaldic and Xanthurenic conjugates.
Storage buffer: Before use, vial should be resuspended in 50 µL of ultrapure water. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze / thaw cycles
Affinity & Specificity:
Competitive ELISA highlights that low amounts of conjugated Kynurenic acid are required to abolish antigen-antibody reaction (high affinity), while rising concentrations of analog conjugates (Quinaldic and Xanthurenic acid) affect only to a lesser extent the reaction (high specificity).
Kynurenic acid (KYNA) Background
L-tryptophan catabolism via the kynurenine pathway produces a range of neuroactive metabolites, including neurotoxic quinolinic acid and its neuroprotective counterpart: kynurenic acid. Known for its antagonistic activities on the NMDA receptor and the a7-nicotinic cholinoceptor (a7NR), Kynurenic acid has recently been described as an endogenous ligand of the orphan G-protein-coupled receptor GPR35.