Kynurenic Acid Polyclonal Antibody

$970.00

The Kynurenic Acid Polyclonal Antibody proved to work at 1/2000 dilution on paraffin-embedded tissues; (a single vial caters approximately 400 stainings). The Eagle Biosciences Kynurenic Acid Polyclonal Antibody is for research use only.

SKU: IS1011 Categories: ,

Kynurenic Acid Polyclonal Antibody

The Kynurenic Acid Polyclonal Antibody is For Research Use Only

Synonyms: Kynurenic acid polyclonal antibody, 4-Hydroxyquinoline-2-carboxylic acid polyclonal antibody, KYNA polyclonal antibody

Immunogen: Conjugated Kynurenic Acid

Specificity: When tested in competitive ELISA, the anti-Kynurenic polyclonal antibody did not show any significant cross reactivity with Quinaldic and Xanthurenic conjugates.

Size</strong: 50µl

Storage: 4°C
Storage buffer: Before use, vial should be resuspended in 50 µL of ultrapure water. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze / thaw cycles
Affinity & Specificity:
Competitive ELISA highlights that low amounts of conjugated Kynurenic acid are required to abolish antigen-antibody reaction (high affinity), while rising concentrations of analog conjugates (Quinaldic and Xanthurenic acid) affect only to a lesser extent the reaction (high specificity).


Kynurenic acid (KYNA) Background

L-tryptophan catabolism via the kynurenine pathway produces a range of neuroactive metabolites, including neurotoxic quinolinic acid and its neuroprotective counterpart: kynurenic acid. Known for its antagonistic activities on the NMDA receptor and the a7-nicotinic cholinoceptor (a7NR), Kynurenic acid has recently been described as an endogenous ligand of the orphan G-protein-coupled receptor GPR35.


Related Products

Quinolinic Acid Polyclonal Antibody
Anti-Conjugated Xanthurenic Acid Polyclonal Antibody

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Please note: All documents above are for reference use only and should not be used in place of the documents included with this physical product. If digital copies are needed, please contact us.