Human CD86 ELISA Assay
The Human CD86 ELISA Assay is For Research Use Only
Size: 1×96 wells
Sensitivity: 0.6 U/ml
Dynamic Range: 1.187 U/ml – 38 U/ml
Incubation Time: 2h 40min
Sample Type: Serum, Plasma, Cell Culture
Sample Size: 100 µl
Alternative Name: B7-2
CD86 (also known as B7-2) is a transmembrane glycoprotein member of the IgG superfamily. CD86 is expressed on antigen-presenting cells that provide co-stimulatory signals necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 (B7-1) to prime T cells and its co-stimulatory pathway plays an important role in the development of anti-tumour response.
Some studies have shown that CD86 expression by malignant cells is associated with a poor prognosis in both acute myeloid leukemia and multiple myeloma and a decrease of CD86 on PBM in melanoma results in an ineffective immune response.
A high level of soluble CD86 in plasma was described in several diseases: abdominal aortic aneurysm, leukaemia, systemic lupus erythematosus and acute asthma.