Complement Factor P, also known as Properdin, is a positive regulator of the alternative complement pathway. It binds to and stabilizes the C3 and C5 convertase complexes, enhancing complement activation and promoting pathogen clearance. Quantitative measurement of Factor P provides information on the plasma concentration of this key complement protein, distinguishing between normal, deficient, or elevated levels, which can affect immune function. Unlike functional assays, which assess activity, quantitative assays specifically determine the amount of Factor P present.
In research settings, quantitative Factor P measurement is used to study immune system regulation and complement-mediated diseases. Researchers can correlate protein levels with disease severity, inflammatory status, or genetic variations affecting complement regulation. It is particularly useful in experimental models of autoimmunity, infections, and inflammatory disorders, where alterations in Factor P levels may influence disease progression or therapeutic responses.
In clinical settings, Factor P quantification helps diagnose congenital or acquired deficiencies, which can increase susceptibility to infections, especially by Neisseria species. Elevated or reduced Factor P levels may also indicate complement dysregulation in conditions such as atypical hemolytic uremic syndrome (aHUS) or other complement-mediated disorders. Quantitative data can guide clinical decision-making, monitor therapy, and, when combined with functional assays, provide a comprehensive assessment of alternative pathway status.
This product is manufactured in Sweden by Svar Life Sciences.