Complement Factor I ELISA Assay Kit

$1,145.00$1,910.00

The Complement Factor I ELISA Assay Kit is to be used for the in vitro quantitative determination of human CFI in plasma and serum. The Complement Factor I ELISA Assay Kit is intended for laboratory research use only and is not for use in diagnostic or therapeutic procedures.

Complement Factor I ELISA Assay Kit

The Complement Factor I ELISA Assay Kit is For Research Use Only

Sizes: 1 x 96 wells
Sensitivity: 35.1 ng/mL
Dynamic Range: 35.1 – 400 ng/mL
Sample Size: 100 uL
Incubation Time: 3 hours 30 minutes
Sample Type: Serum and Plasma

Controls Not Included


Assay Background

CFI is a protein of the complement system (serine protease) , also known as as C3b/C4f
inactivator, and is a protein that is encoded by the CFI gene located on chromosome 4. It regulates complement activation by cleaving cellbound or fluid phase C3b and C4b. CFI is synthesised predominantly in the liver, and is initially secreted as a single 88 kDa gene product; this precursor protein is then cleaved by furin to yield the mature CFI protein, which is a disulfide-linked dimer of heavy chain residues (residue 19-335, 51 kDa) and light chain (residues 340-583, 37 kDa). Only the mature protein is active. Genetic polymorphism in CFI has been observed (variants R201S, R406H, R502L). CFI deficiency leads to low levels of complement component 3 (C3) in plasma, due to unregulated activation of the complement alternative pathway, and it has been associated with recurrent bacterial infections in children. More recently, mutations in the CFI gene have been shown to be implicated in development of Haemolytic Uremic Syndrome, a renal disease also caused by unregulated complement activation.


Related Products

Rat Classical Complement Pathway ELISA Assay Kit
Mouse Classical Complement Pathway ELISA Assay Kit
Pig Lectin Complement Pathway ELISA Assay Kit
Pig Alternative Complement Pathway ELISA Assay Kit

Documents

Product Manual


Please note: All documents above are for reference use only and should not be used in place of the documents included with this physical product. If digital copies are needed, please contact us.