CH50 ELISA Kit

CH50 ELISA Kit

CH50 is a functional assay used to assess the overall activity of the classical complement pathway, an important component of the innate immune system. The assay evaluates the ability of serum complement components to mediate lysis of antibody-sensitized red blood cells through the coordinated activity of complement proteins C1 through C9. CH50 measurement provides an assessment of the functional integrity of the classical and terminal complement pathways. Reduced CH50 activity may indicate a deficiency, dysfunction, or consumption of one or more complement components.

In research settings, CH50 measurement is used to investigate complement pathway activity and the role of complement in inflammation, autoimmunity, immune complex-mediated processes, and infectious disease. Researchers can use CH50 to study changes in classical pathway function associated with complement deficiencies or experimental conditions that affect complement activation. It can also be used to evaluate changes in complement activity following experimental treatments or interventions targeting the complement system.

In clinical research, CH50 is investigated in association with inherited and acquired complement abnormalities and immune-mediated diseases, including systemic lupus erythematosus (SLE). Decreased CH50 activity may reflect consumption of complement components during immune complex-mediated complement activation and can therefore be studied in relation to disease activity. CH50 can also be investigated in individuals with recurrent infections where complement dysfunction is suspected. When combined with individual complement component measurements and other functional assays, CH50 provides additional information for characterizing classical pathway and overall complement system function.

This CH50 ELISA Kit is manufactured in Italy by Diametra.