Mouse Lipopolysaccharide Binding Protein (LBP) ELISA Kit
Lipopolysaccharide (LPS) Binding Protein (LBP) is a type 1 acute phase protein produced primarily by the liver and rapidly upregulated during the acute phase response. LBP plays a central role in the innate immune response to lipopolysaccharide (LPS), a component of the outer membrane of Gram-negative bacteria. It binds LPS and facilitates its recognition by immune cells, including monocytes and macrophages, promoting the release of inflammatory mediators. LBP also participates in the neutralization and clearance of LPS by facilitating its transfer to lipoproteins and subsequent removal from the circulation. In mice, circulating LBP levels can increase substantially during acute phase responses, and concentrations may vary depending on sample type and mouse strain.
In research settings, LBP is widely studied as a biomarker of innate immune activation, inflammation, and responses to bacterial endotoxin. Researchers measure LBP levels in serum, plasma, and other biological samples to investigate inflammatory responses in experimental models of infection, sepsis, metabolic disorders, and other inflammatory conditions. LBP measurements can also be used to evaluate the effects of genetic modifications, environmental factors, or experimental treatments on LPS-mediated immune responses.
In clinical research, LBP is investigated as a biomarker associated with systemic inflammation and endotoxin exposure. Changes in LBP levels have been studied in conditions involving bacterial infection, inflammatory disorders, and metabolic dysfunction. Measuring LBP alongside other inflammatory and immune biomarkers can provide additional insight into LPS-mediated immune activation and the mechanisms underlying inflammatory responses.
This Mouse Lipopolysaccharide Binding Protein (LBP) ELISA Kit is manufactured in Netherlands by Hycult Biotech.
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