210 ELISA, manufactured by AroCell is offered in EagleBio’s Cancer Biomarker Assay Line. The Cancer
Biomarker Assay Kit Line offered Eagle Biosciences provides a comprehensive
array of sensitive and valuable tools to assist researchers in new emerging
market segments in cancer research such as tumor marker and anti-tumor therapy
210 ELISA is a convenient, simple test as well as the most sensitive
ELISA for measuring TK1.
Why Measure Thymidine Kinase 1 (TK1)?
The enzyme Thymidine Kinase 1 (TK1) is up-regulated in
tumor cells from which it is released into the blood during their turnover.
Increased serum TK1 protein has been discovered to be associated with tumor
growth. TK1 up-regulation may be an early event in cancer development and TK1
may even be elevated in pre-cancerous conditions.1
Although TK1 activity is a valuable biomarker it has
limitations in that most current methods are based on enzyme activity
assays.The AroCell TK 210 ELISA test, based on two monoclonal antibodies
specific for a unique TK1 amino acid sequence (194-225), brings the
specificity, sensitivity and robustness of immunoassay to the assay of serum
Key Advantages of TK 210 ELISA:
Sensitive ELISA for measuring TK1
ELISA procedure with same day results
measure both Active & Inactive TK1
tumors do not affect results unlike other methods for measuring TK1
Evidence that TK210 can be used successfully with traditional cancer
markers like CA15-3
with both Serum or Tissue samples
M.M. et al. (2012). Thymidine Kinase 1 Upregulation Is an Early Event in Breast
Tumor Formation. Journal of Oncology. Volume 2012, 5 pages.
J.K. et al. (2016). A Clinical Evaluation of the TK 210 ELISA in Sera from
Breast Cancer Patients Demonstrates High Sensitivity and Specificity at All
Stages of the Disease. Tumor Biology. DOI 10.1007/s13277-016-5024-z (Epub ahead