MSH2 Mouse Monoclonal Antibody
The MSH2 Mouse Monoclonal Antibody is for research use only
Clone #: BPM6143
Form: Liquid
Predicted Molecular Weight: 105 kDa
Purity: ProG affinity purified IgG
Species Cross-reactivity: Human
Applications: IHC-P
Background:
MSH2 is a 105 kDa nuclear antigen and encodes a protein of 934 amino acids. The MSH2 antibody gene is one of only 4 known to encode proteins involved in the repair of mismatch nucleotides following DNA replication or repair. Mutations in the MSH2 gene contribute to the development of sporadic colorectal carcinoma. MSHS mutations are responsible for 50% of hereditary non-polyposis colorectal cancer (HNPCC). The repair of mismatch DNA is essential to maintaining the integrity of genetic information overtime. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair.
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