GFAP Recombinant Rabbit Monoclonal Antibody
The GFAP Recombinant Rabbit Monoclonal Antibody is for research use only
Clone #: BP6061
Form: Liquid
Predicted Molecular Weight: 50 kDa
Purity: ProA affinity purified IgG
Species Cross-reactivity: Human
Applications: IHC-P
Background:
GFAP (Glial fibrillary acidic protein)is an intermediate filament protein. The protein is the smallest (8 nm) of the intermediate filament proteins with a molecular weight of about 50 kDa.
In the central nervous system, GFAP is expressed in astrocytes and ependymal cells but not in other glial cells. However, immature oligodendrocytes and immature choroid plexus cells may be GFAP positive. In the peripheral nervous system enteric Schwann cells and satellite cells of human sensory ganglia express GFAP. Outside the nervous system, GFAP is seen in myoepithelial cells and chondroblasts. In tumor tissues, astrocytoma, ependymoma, glioblastoma, and oligodendroglioma are almost always positive. Plexus carcinoma, ganglioglioma and primitive neuroectodermal tumors (PNET: neuroblastoma a.o.) express GFAP to a varying extent. Schwannoma and neurofibroma frequently express GFAP. Chondroma, chondrosarcoma and pleomorphic adenoma are also GFAP positive in most cases. A few carcinomas (especially from lung and breast) may express GFAP in paraganglioma GFAP may be detected in sustentacular cells.
GFAP is used to differentiate astrocytoma from non-glial cell tumors.
Related Products
LAG-3 Recombinant Rabbit Monoclonal Antibody
CTLA-4 Recombinant Rabbit Monoclonal Antibody
Tim-3 Recombinant Rabbit Monoclonal Antibody
