Mouse Anti-Rat Brevican Monoclonal IgG2B Antibody
Brevican is the most abundant chondroitin sulfate proteoglycan (CSPG) in the adult brain’s extracellular matrix and a prominent member of the lectican family. Highly enriched in the central nervous system, Brevican plays a critical role in maintaining synaptic architecture and modulating neural plasticity. It is secreted by both astrocytes and neurons as a 145 kDa core protein, either with or without covalently attached chondroitin sulfate (CS) chains.
Functionally, Brevican contributes to the formation and stabilization of perineuronal nets (PNNs), specialized extracellular matrix structures that regulate synaptic signaling and restrict plasticity in the mature brain. This inhibitory role is essential for preserving neural circuitry but may also limit regenerative capacity following injury or in neurodegenerative conditions.
Importantly, Brevican is proteolytically cleaved by ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family enzymes, generating a 55 kDa N-terminal fragment containing the disease-relevant EAMESE epitope. This cleavage event is associated with synaptic remodeling and has been implicated in pathological processes such as gliosis, epilepsy, and Alzheimer’s disease.
Given its dual role in synaptic stabilization and plasticity inhibition, Brevican is emerging as a key molecular target in neurodegenerative disease research. Modulating its expression or cleavage may offer novel therapeutic strategies to enhance neural repair and cognitive resilience in aging and disease.
This Mouse Anti-Rat Brevican Monoclonal IgG2B Antibody is manufactured in Canada by StressMarq.
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