Creatinine is a small nitrogenous waste molecule produced at a fairly constant rate from the breakdown of creatine phosphate in skeletal muscle. Because its generation is closely tied to muscle mass and is not significantly affected by diet or metabolic fluctuations, creatinine serves as a stable endogenous marker of renal filtration. In healthy individuals, it is freely filtered by the glomeruli with minimal tubular reabsorption, allowing its concentration in blood and urine to reliably reflect kidney function.
In clinical practice, serum creatinine is one of the most widely used indicators for assessing renal health. It forms the basis of estimated glomerular filtration rate (eGFR) calculations, which help diagnose and stage chronic kidney disease, evaluate acute kidney injury, and monitor progression or treatment response. Creatinine clearance, measured through timed urine collection, provides a more direct assessment of filtration capacity when higher accuracy is needed. Changes in serum or urinary creatinine can guide medication dosing, fluid management, and decisions around nephrotoxic exposures.
In research settings, creatinine is commonly used as a normalization factor for urinary biomarker studies, helping adjust for variations in urine concentration. It is also used in preclinical and clinical studies investigating renal physiology, nephrotoxicity, and drug pharmacokinetics. Because it is a fundamental marker of kidney filtration, creatinine remains a critical anchor measurement across nephrology, toxicology, pharmacology, and biomarker validation studies.
This product is manufactured in Canada by StressMarq.
| Size | 2 x 96 Well |
| Sensitivity | 0.085 mg/dL |
| Dynamic Range | 0.5 – 4 mg/dL |
| Sample Type | Serum, Plasma |
| Storage | 2-8°C |
| Alternative Names | Methylguanidoacetic acid, N-Carbamimidoyl-N-methylglycine |