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New Partners
FGF-21 Biomarker Spotlight
New Complement Assays
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A teen died recently of the Septicemic plague which is serious illness that occurs when the the bacterium Yersinia pestis enter the bloodstream directly and spreads throughout the body. Yersinia pestis was responsible for killing millions of people in the 1300s in Europe, in a pandemic known as the Black Death. This bacteria is carried by rodents such as rats, ground squirrels, and prairie dogs (and their fleas) and is prevalent in the western United States.
The young man of 16 years old who contracted this disease,Taylor Gaes was the first person in Larimer County to get the plague since 1999. There is a an active investigation to determine how he was infected but they believe he may have been bit by infected fleas on his family’s property.
Unfortunately, the symptoms of the plague can present like the flu, thus they are often misinterpreted which was the case for Taylor. After a few days of being ill, he began coughing up blood and was rushed to the hospital but he died before arriving there. Read More
Routes of Contraction of the Plague:
Symptoms:
Symptoms appear 2 to 6 days after exposure to plague bacteria.
Click Here for more signs, symptoms, facts, and prevention tips on the plague.
image above from www.livescience.com
June 2015: Eagle Biosciences, Inc. is pleased to announce a North American
distribution agreement with Mediagnost in Germany. Mediagnost offers a wide
range of top-notch biotechnology services and products which include test
systems for multiple applications. They have a unique focus on the advancement
of Hepatitis A vaccine and the development of endocrine testing methods. Mediagnost’s core research and development projects
encompass the areas of infectious diseases, endocrinology, and neurology.
“I am
thrilled to bring Mediagnost products to EagleBio and add them to our product
offerings.” said Dan Keefe, President of Eagle Biosciences. He continued, “This
certainly is a great opportunity for Eagle as we are establishing a new
strategic partnership with a group of scientific experts that are constantly
driving forward the identification of innovative biomarkers.”
This
product is currently for research use only. Visit the Eagle our website www.EagleBio.com or call 866-411-8023 for full details.
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Recent research at the Scripps Research Institute focused on developing a new drug by investigating a protein known as PPARG (known as the master regulator of fat) and how it can affect the stem cells of the bone marrow.The team of scientists in the Translational Research Institute at Scripps has designed a compound called SR2595 to be used it to repress the PPARG protein. Their studies revealed that by reducing PPARG, they were able to promote bone formation by inducing the formation of osteoblasts (cells that help bone tissue to form).
PPARG’s close relation to several proteins with known roles in disease provides hope for endless therapeutic opportunities. This is a ground-breaking discovery because this drug target not only could treat and possibly cure numerous bone-related diseases, but it also has enormous potential to treat a variety of other diseases. Read More
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EagleBio’s FGF23 (C-terminal) ELISA: Product Highlights
January 2015: Eagle Biosciences Introduces New FGF23(C-Terminal) ELISA Assay
30% Discount on our:
This promotion is good through July 31st, just use code below when ordering.
PROMOTIONAL CODE: COMP0731
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Immunology Assay Kits
Related News:
EagleBio Spotlight: Complement System
The complement system is a crucial part of the immune system which assists antibodies and phagocytic cells to clear pathogens from an organism. It is an elaborate protein network of effectors, inhibitors and regulators that is the driving force for critical processes involving overall health as well as disease states. This system continuously communicates with associated physiological pathways such as immunity, inflammation, homeostasis, and development.
The complement system is made up of over 50 plasma and membrane-bound proteins that interact in a cascade fashion. There are three key biochemical pathways that trigger the complement system: the classical pathway, the alternative pathway, and the lectin pathway. These pathways trigger the generation of biologically active molecules that play crucial roles in numerous physiological and pathological processes as mentioned above.
Classical Pathway: the pathway activated by C1 binding either directly to bacterial surfaces or to antibody for the purpose of identifying and flagging bacteria as foreign.
Alternative Pathway: the pathway activated by the binding of complement protein C3b to the surface of a pathogen. This pathway is a key component of innate immunity and has a role in boosting the work of classical pathway.
Lectin Pathway: the pathway activated by binding of MBL (mannose-binding lectin) to mannose residues on the pathogen surface.
Figure 1: Complement Overview
Reasons for Measuring the Complement System:
The complement system plays intricate and vital roles in both the innate and the adaptive immune defense and it is acts a bridge between these two facets of immunity. Complement deficiencies and other molecular abnormalities in this system result in increased infection and increased risk for autoimmune and numerous other diseases. The increased awareness and interest in the complement system has prompted the need for a simple, objective, and effective method to assess the function of complement activity. Measuring various parts of the complement pathway gives insights to researchers for various disease states as well as for potential therapeutic targets.
Table
1: Complement Deficiencies and Associated
Infections (Skattum et. al)
References and Relevant Publications:
5. Yang, Kun, et. al. “CMAP: Complement Map Database.” Bioinformatics. 2013 Jul 15; 29(14): 1832–1833.
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FGF-23 (C-Terminal) ELISA is for Research Use Only, Not to be used for diagnostic procedures.
Eagle Biosciences’ Bone Metabolism Line is a comprehensive portfolio of assays for detecting and monitoring numerous biomarkers for the regulation of bone and mineral homeostasis, assisting researchers in various fields of study. One unique kit offered in our Bone Metabolism Line is our FGF23 (C-Terminal) ELISA which offers highly sensitivity, versatility with use of multiple sample types with excellent stability, and valuable results in emerging areas of research. Our FGF23 (C-Terminal) ELISA assay provides incredible value and unique insights for research surrounding the investigation new biomarkers that could improve prediction of CKD progression, as well as the discovery of new drug targets.
Why Measure FGF23 with EagleBio’s Assay?
EagleBio’s FGF23 ELISA is the most specific kit in the market, uniquely
designed to detect both Intact and C-Terminal fragments.
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January 2015: Eagle Biosciences Introduces New FGF23 (C-Terminal) ELISA
Assay
A recent test has been developed at Harvard Medical School and Brigham and Women’s Hospital by a genetics professor, Stephen J. Elledge. This blood test, called the VirScan Test works by detecting antibodies to viruses known to infect humans for close to the entire human virome. So in other words, this test can pick up antibodies that the immune system has made in response to viruses to almost every virus known to infect people.
This technology was tested in cohort of individuals across various countries including the United States, Peru, Thailand, and South Africa, all of whom were known to carry certain viruses. The test was successful in detecting more than 90 percent of known infections, viruses that the study participants were not known to have had, and the test rarely gave false positives.
This test could quite possibly become an valuable tool for tracking disease patterns as wells as countless other clinical and scientific applications. It may be possible to use the VirScan method to study viruses suspected of playing a role in initiating autoimmune diseases such as Type I diabetes and multiple sclerosis. Another application of this test may be to examine cancer and why the disease progresses faster in some patients compared to other patients and why chemotherapy make work better is some people. Other possibilities may be to explore viruses in children in large populations to determine what ages at which children are exposed to various illnesses in order to help determine the best timing for vaccinations.
The VirScan Test certainly has amazing potential in a variety of areas surrounding the immune response but more research and more studies will help to improve and understand how best to put it to use. Read More
image from www.chicagotribune.com
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A recent study conducted by MIT and the University of California, San Diego utilized engineered Escherichia coli bacteria (harmless strain) to colonize metastasizing tumors in mice. This cohort of mice were given the bacteria orally and once inside their bodies, the bacteria fed off of and gained energy from the dying cells inside the necrotic core of tumors. At the same time this process was occurring, the researchers injected a sugar solution containing a molecule called luciferin, a protein that causes the glow in fireflies. The E.coli was engineered specifically to produce an enzyme that would cause it to split the galactose sugar from luciferin. Then the luciferin would filter its way through the body by way of the kidneys and thus be excreted in the urine and changing the color of mice’s urine red in those with metastasizing tumors.
This new method shows amazing promise as the bacteria can be designed to pick up any chemical or biomarker. This type of test could really make a difference in the future, allowing for earlier and easier diagnosis of various diseases/conditions. In particular, there is hope that it could eliminate the need for some invasive biopsies and may greatly enhance the ability to detect minute concentrations of analytes that other tests cannot pick up. Read More
image above from: www.livescience.com
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