S100A7 ELISA Kit

S100A7 (psoriasin) is a 11.4kDa member of the S100 gene family, which are EF-hand Ca 2+-
binding proteins. They are involved in a broad range of intra- and extracellular processes like
regulation of calcium homeostasis, cell proliferation, differentiation, apoptosis, immune
responses, antimicrobial activity, chemotaxis and inflammation. S100 proteins have a
fundamental structural unit which is a highly integrated dimer, some as homodimer and others
as heterodimer. S100A7 functions as a homodimer and binds two Zn2+ ions. These ions
stabilize the dimer and mediate the function of S100A7 during infection. Extracellular S100A7
functions as a DAMP during infection. S100A7 limits bacterial infection through metal limitation.
Furthermore, S100A7interacts with RAGE which drives an NFresponse and recruitment of neutrophils.
S100A7 was first discovered as a protein abundantly expressed in psoriatic keratinocytes.
Psoriasis is considered a disease of dysregulated epidermal hyper proliferation and
inflammation, initiated by multiple mechanisms of the immune system. Possibly, S100A7
adheres directly to and reduces survival of pathogens found on the epidermis and acts as a
physical barrier. Originally S100A7 was called a biomarker for psoriasis, but is also find in other
skin diseases like atopic dermatitis. Therefore, the protein seems to be a major player in the
local innate defense of the skin. Furthermore, S100A7 seems to be involved with breast cancer
and squamous cell carcinoma. In vitro it was found to confer a more aggressive behavior.
It is strongly recommended to wear gloves. Please be aware the assay is sensitive for any skin
or hair flakes: this can give false positive results.

This product is manufactured in Netherlands by Hycult Biotech.