Rat NT-proBNP (N-terminal pro B-type Natriuretic Peptide) is a cardiac biomarker commonly used in translational research to evaluate cardiac stress, ventricular dysfunction, and heart failure models in rodent studies. NT-proBNP is a cleavage product of the prohormone proBNP, released from ventricular cardiomyocytes in response to increased wall stress, pressure overload, or volume expansion. While its biological role in rats parallels that in humans, the sequences are species-specific, and validated rat-specific assays are necessary for accurate measurement.
In research settings, rat NT-proBNP is used to monitor heart function in preclinical models of cardiovascular disease, such as myocardial infarction, hypertensive heart disease, and drug-induced cardiotoxicity. It serves as a sensitive biomarker for early detection of cardiac dysfunction in toxicology studies and efficacy trials of cardiovascular drugs. Because it is stable in plasma and correlates well with disease progression, NT-proBNP is valuable for both longitudinal and endpoint measurements in rodent studies.
Although not used clinically in rats, rat NT-proBNP serves as a surrogate biomarker to predict translational relevance of cardiovascular therapies and toxicities prior to human trials. Its measurement can support regulatory safety packages by demonstrating pharmacodynamic effects or cardiac safety margins. As such, rat NT-proBNP plays a critical role in bridging preclinical cardiac findings to human clinical outcomes.
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