Rabbit Anti-Rat SAP97 Recombinant Monoclonal IgG Kappa Antibody
SAP97 (Synapse-Associated Protein 97), a member of the MAGUK family, is a critical scaffolding protein involved in the trafficking and localization of glutamate receptors, which are essential for synaptic plasticity and cognitive function. Mutations in the DLG1 gene encoding SAP97 have been linked to schizophrenia, with studies showing that these mutations enhance glutamatergic synapse strength in the dentate gyrus and impair episodic memory processing. SAP97 also mediates a non-conventional secretory pathway for NMDA receptors via dendritic Golgi outposts, highlighting its unique role in receptor sorting and synaptic regulation. Furthermore, SAP97 regulates the trafficking of ADAM10, a key α-secretase involved in amyloid precursor protein processing, implicating it in Alzheimer’s disease mechanisms. Our Anti-Rat SAP97 recombinant monoclonal antibody has been demonstrated to detect the target in rodent brain lysates and in cell culture lines.
This Rabbit Anti-Rat SAP97 Recombinant Monoclonal IgG Kappa Antibody is manufactured in Canada by StressMarq.
