Rabbit Anti-Human WNK1 (pSer382) Polyclonal Antibody
WNK1 (With No Lysine [K] Kinase 1), particularly in its phosphorylated form at serine 382 (pSer382), plays a central role in regulating neuronal ion transport and cellular volume—processes that are critically disrupted in neurodegenerative diseases. As a master kinase, WNK1 activates downstream effectors such as SPAK and OSR1, which control the activity of cation-chloride cotransporters like NKCC1 and KCC2. These transporters are essential for maintaining chloride balance, synaptic inhibition, and overall neuronal excitability.
In the brain, WNK1 (pSer382) responds to osmotic stress and changes in intracellular chloride levels, initiating signaling pathways that influence neuron survival, glial cell function, and cerebrospinal fluid regulation. Dysregulation of this pathway has been associated with brain edema, ischemic injury, and chronic neuroinflammation—key features of disorders such as Alzheimer’s disease, Parkinson’s disease, and epilepsy.
Targeting WNK1 phosphorylation, especially at Ser382, is emerging as a promising therapeutic strategy. By restoring ionic equilibrium and modulating neuroinflammatory responses, WNK1 (pSer382) offers a novel entry point for interventions aimed at slowing or preventing neurodegeneration.
As research progresses, WNK1 (pSer382) is gaining recognition as a critical molecular link between ion homeostasis and brain health, with broad implications for neuroscience and neurotherapeutics.
This Rabbit Anti-Human WNK1 (pSer382) Polyclonal Antibody is manufactured in Canada by StressMarq.
