NGAL Plasma ELISA Kit
Neutrophil Gelatinase-Associated Lipocalin (NGAL), also known as lipocalin-2, is a 25-kDa glycoprotein originally identified as a component of neutrophil secondary granules. It belongs to the lipocalin protein family, which binds and transports small hydrophobic molecules. NGAL is rapidly upregulated and secreted in response to cellular stress, particularly in renal tubular epithelial cells following injury. Because of this, it has emerged as a sensitive and early biomarker for acute kidney injury (AKI), often detectable in blood and urine within a few hours of renal insult—well before conventional markers like serum creatinine rise.
In clinical settings, NGAL measurement is used to detect and monitor AKI across a variety of contexts, including cardiac surgery, sepsis, and contrast-induced nephropathy. It has also been investigated as a prognostic indicator for chronic kidney disease (CKD) progression and as a marker of renal recovery. Beyond nephrology, NGAL is gaining interest as a biomarker in oncology and inflammatory conditions; for instance, it is overexpressed in certain cancers (e.g., breast, colorectal, and pancreatic) and may reflect tumor aggressiveness and metastasis potential.
In research, NGAL serves as a valuable tool for elucidating the molecular mechanisms of kidney injury, inflammation, and iron metabolism. Its rapid response to cellular damage makes it useful for evaluating nephrotoxicity in preclinical drug studies and for exploring the pathophysiology of renal and systemic diseases. As assays for NGAL (such as ELISA and point-of-care tests) become more standardized and widely available, its role continues to expand in both translational and clinical research settings.
This NGAL Plasma ELISA Kit is manufactured in USA by Eagle Biosciences.
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