Lipopolysaccharide (LPS) Binding Protein (LBP) is a type 1 acute phase protein that is constitutively produced by the liver and rapidly upregulated during the acute phase response. LBP plays a central role in the response to (LPS). The protein catalyses the monomerization of activation pathway of LPS: activation of monocytes by LPS leading to release of inflammatory mediators and in the neutralization of LPS i.e. the uptake of LPS by lipoprotein and subsequent clearing. In plasma of normalmice LBP is present at levels of approx. 6 µg/mL, which increase. 10-fold during acute phase responses. The amount of LBP can change per sample type and mouse strain.
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