Mouse Anti-Human LAR (PTPRF) Monoclonal IgG2a Antibody
LAR (Leukocyte Common Antigen-Related Protein), encoded by PTPRF, is a receptor-type protein tyrosine phosphatase involved in neural development and regeneration. It regulates cell adhesion, cytoskeletal dynamics, and synaptic plasticity by dephosphorylating β-catenin and modulating cadherin-mediated junctions. LAR influences neurite outgrowth, axon guidance, and actin remodeling, making it critical for neurodevelopment and repair. In neurodegenerative contexts, LAR dysregulation may impair synaptic stability and neuronal connectivity. Its role in insulin signaling and inflammation further links it to metabolic and neurodegenerative disorders. As a modulator of synaptic architecture and signaling, LAR represents a potential target for therapeutic strategies aimed at restoring neural function.
This Mouse Anti-Human LAR (PTPRF) Monoclonal IgG2a Antibody is manufactured in Canada by StressMarq.
Size
100 µg
Immunogen
Fusion protein amino acids 1315-1607 (cytoplasmic C-terminus) of human LAR. 97% identical in both rat and mouse. >80% identity with PTPRD and PTPRS. >50% identity with PTPRM and PTPRK.
Immunogen Species
Human
Host Species
Mouse
Clone
N165/38 (Formerly sold as S165-38)
Purification
Protein G Purified
Concentration
1 mg/mL
Specificity
Detects ~85kDa (full length protein is 210 kDa – smaller due to proteolysis into P-subunit containing transmembrane and intracellular domains.
Alternative Names
PTPRF, LAR, Leukocyte antigen related, Leukocyte antigen related PTP receptor, Leukocyte antigen related tyrosine phosphatase, Leukocyte common antigen related, Receptor-type tyrosine-protein phosphatase F, Receptor type tyrosine protein phosphatase F precursor, Protein Tyrosine Phosphatase Receptor Type F, Protein tyrosine phosphatase receptor type F polypeptide, Receptor linked phosphatase LAR, LAR protein, LARS, LARFN5C, LCA homolog, FLJ43335, FLJ45062, FLJ45567
